Qualifications: BSc (Hons) (1990), PhD (1994) Cambridge University (UK)
+61 430 913031
ashley@ptngconsulting.com
ptngconsulting.com
linkedin.com/in/ashleybuckle
I have more than three decades of expertise in structural biology and protein engineering, with a focus on combining state-of-the-art protein biochemistry, biophysical, structural and computational approaches in protein engineering programs. I have published more than 145 peer-reviewed scientific papers in high impact journals that include Science, PNAS (10), Nature Struct. Mol. Biol. (2), Nature Chem. Biol., Nature Communications and Nature Immunology (2), and delivered more than 100 research seminars. I have secured in excess of AUD$15 million in research funding and am the named co-inventor on 7 patents. In 2020 I founded PTNG Consulting, specialising in providing solutions in structural biology, protein engineering and design, and computational biology. Current clients include Biotechnology companies and academic institutions worldwide. In collaboration with partners from industry and academia, PTNG is also using protein engineering approaches to create a toolbox of novel synthetic protein therapeutics, notably antibodies, antibody-like proteins and serine protease inhibitors. In 2021 I founded Biovidera, a molecular visualisation and animation company. I currently hold an Adjunct Associate Professor appointment at the Department of Biochemistry and Molecular Biology, Monash University, Australia. Further details at ORCID: https://bit.ly/2PyU9mX.
Date | Description |
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2021 – present | Biovidera (CEO & founder). A molecular visualisation and animation company. |
2020 – present | PTNG Consulting (CEO & founder). Consultancy in Protein Engineering. https://www.ptngconsulting.com |
2020 – present | Adjunct Associate Professor, Dept of Biochemistry & Molecular Biology, Monash University (https://bit.ly/36ohyxl). |
2007 – 2020 | Head, Protein Engineering and Design Lab/Associate Professor, Dept of Biochemistry & Molecular Biology, Monash University, Australia. |
2007 – 2012 | NHMRC Senior Research Fellowships. |
2014 | Visiting Professor at the Sapienza Università di Roma, Italy. |
2013 | Erskine Fellowship (visiting Professor), University of Canterbury, Christchurch, NZ. |
2012 | Visiting Professor, Ecole Normale Supérieure de Cachan, Paris, France. |
2003 – 2006 | Senior Research Fellow, Dept. Biochemistry, Monash University. |
1999 – 2003 | Biodesigns Ltd (founder). Consultancy in bioinformatics. Clients: Cambridge University Transfusion Medicine; National Blood Service, UK. |
1999 – 2003 | Senior Staff Scientist (tenured), MRC Centre for Protein Engineering, Cambridge, UK. |
1999 – 2001 | Consultant for Avidis (now Imaxio after merger with Diagnogene). Avidis developed recombinant protein refolding technology based upon my postdoctoral work on minichaperones. |
1994 – 1999 | Postdoctoral Fellow, MRC Cambridge, UK, group of Sir Alan Fersht, a founder and pioneer of protein engineering. Training in X-ray crystallography at the MRC Laboratory of Molecular Biology, Cambridge, the birthplace of structural biology. |
1990 – 1995 | Consultant for Cambridge Antibody Technology UK (molecular modelling). Acquired by AstraZeneca in 2006 for £702m. |
1988 – 1989 | Ciba-Geigy Pharmaceuticals (now Novartis), Horsham, UK. Research student in Advanced Drug Delivery Research Unit (1 year of BSc degree). |
Date | Description |
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1990 - 1994 | PhD (Biochemistry), University of Cambridge (UK), group of Sir Alan Fersht (FRS). |
1990 | Medical Research Council (UK) Postgraduate Scholarship, University of Cambridge. |
1990 | Bachelor of Science (Honours; Chemistry), Kingston University (UK). |
15 years’ experience assessing funding applications: Wellcome Trust, European Research Council, MRC UK, Human Frontiers, Cure Cancer Australia, NHMRC, ARC, Austrian START, Marsden Fund NZ, Prostate cancer foundation, Health Research Foundation of NZ, and Worldwide Cancer Research. NHMRC (Australia) Project grant panel (Biochemistry, 2015-2017) and Monash University strategic grants panel (2015-2018).
149 publications, H-index = 46, >7000 citations.
Complete list at Google Scholar (https://bit.ly/2oj9zAe) & PubMed (https://bit.ly/31Md0gA).
Name | Description |
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D2Odb | A database of predicted structural transitions for mutations in human proteins (https://d2odb.org/). |
REFOLDdb | Tool for the optimization of protein refolding (https://bit.ly/32G57eE). |
PolyQ | Sequence and domain context of polyglutamine repeats in proteins (https://bit.ly/2NfpWq0). |
KINETOCHORE | Database for kinetochore proteins (https://bit.ly/36c9qjp). |